DOI: https://doi.org/10.30978/UTJ2018-3-4-62

Антиоксидантна активність у пацієнтів із хронічним обструктивним захворюванням легень та ішемічною хворобою серця

O. O.  Krakhmalova, L. M.  Samokhina, Yu.  E.  Kharchenko

Анотація


Вивчено нові дані про роль антиоксидантної системи в механізмах патогенезу хронічного обструктивного захворювання легень (ХОЗЛ) і в поєднанні з ішемічною хворобою серця (ІХС). Визначено ефективний мікрометод оцінки загальної антиоксидантної активності в плазмі крові людини. Зауважено неоднозначний характер змін системи оксиданти/антиоксиданти при ХОЗЛ, а також на тлі впливу сигаретного диму. Показано, що при загостренні кардіореспіраторної патології реакції вільнорадикального окислення посилюються, але з віком спостерігається неспецифічність змін. Наведено дані про ефективність різних препаратів антиоксидантної дії в лікуванні ХОЗЛ і в поєднанні з ІХС. Окреслено перспективи розвитку досліджень в індивідуальному підборі лікарських засобів.

Ключові слова


система оксиданти/антиоксиданти; загальна антиоксидантна активність; сигаретний дим; хронічне обструктивне захворювання легень; ішемічна хвороба серця; препарати антиоксидантної дії

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