Поліморфні варіанти A1166C гена АТІІR1 у хворих на серцево-судинну патологію

O. V. Petyunina

Анотація


В огляді представлено аналіз даних щодо ролі поліморфних варіантів A1166C гена рецепторів 1 типу до ангіотензину ІІ (АТІІR1) при артеріальній гіпертензії, серцевій недостатності, інфаркті міокарда. Показано, що ген АТІІR1 є геном-кандидатом, якому притаманні властивості самостійного фактора серцево-судинного ризику. Поліморфізм А1166С гена ATIIR1 асоціюється не тільки з модифікацією ефектів ренін-ангіотензин-альдостеронової системи, а й їхнім впливом на перебіг серцево-судинних захворювань та фенотиповими проявами.

Ключові слова


поліморфізм гена ATIIR1 А1166С; серцево-судинні захворювання.

Повний текст:

PDF

Посилання


Ashkanova T.M., Muzhenia D.V., Pshidatok A.R. i soavt. Prognosticheskaia rol А1166С polimorphismov gena receptora 1 typa angiotensina ІІ (AGT2R1) pro coronarnom aterosklerose u zhitelei respubliki Adygeia // Rossiiski Kardiologicheski Zhurnal. –2015. -Т.10(126). –S.19-23 [in Rus].

Babaiev A.M., Zulfugarova Dzh.B. Rol nasledstvenno-geneticheskich factorov v etiologii, razvitii I techenii IBS // Biomeditsina. –2016. -№3. –S. 6-12 [in Rus].

Babaiev A.M., Ibragimova I.D. Geneticheskiie aspekty arterialnoi gipertensii // Biomeditsina. –2016. –№3. –S. 12-20 [in Rus].

Berkovich O.A., Bazhenova Е.А., Volkova E.V. i soavt. А1166С polymorphism receptora 1 typa angiotensina II I dysfunktcia endoteliia u muzhchin, perenesshich infarct miocarda v molodom vozraste // Rossiiski Kardiologicheski Zhurnal. –2000. –№6(26). –S. 5-9 [in Rus].

Zhebel V.M., Starzhynska O.L., Gefter Y.O. ta spivavt. Genotyp receptora do angiotensynu II 1-go typu yak factor vplyvu na strukturu ta funktciiu myocardia u chvorych na hypertonichnu chvorobu riznoii tiazhkosti // Arterialna Hypertensiia. –2009. –№ 1(3). –S.24-29 [in Ukr].

Kaidashev I.P., Zhdan V.M., Rasin M.S. i soavt. Molekuliarno-biologicheskiie aspekty hipertonicheskoi bolezni: rol polimorphisma belkov renin-angiotensinovoi systemy i receptorov, aktiviruyushchich proliferatsiiu peroxikom // Ukrainski kardiologichny zhurnal. –2010. –Dodatok 1 [in Rus].

Karpenko M., Satskaia E.G., Solntsev V.N. i soavt. Ostrie cerebrovascularniie katastrofy u bolnych arterialnoi hypertensiiei: molekularno-geneticheskiie aspekty // Ratsionalnaia farmakoterapiia v kardiologii. –2008. –№1. –S.33-38 [in Rus].

Кокоrin V.А., Sytnik N.V., Dudareva A.V. i soavt. Activnost renin-angiotensin-aldosteronovoi I simpato-adrenalovoi system u bolnych v otdalenniie sroki posle pervichnogo infarcta miocarda // Rossiiski Kardiologicheski Zhurnal. –2009. –№4 (78). –S.17-21 [in Rus].

Sydorchuk L.P. Pokaznyky echokardiogramy ta geometrychni modeli miokarda livogo shlunochka u chvorych na arterialnu hypertensiiu zalezhno vid polimorfismu piatoch geniv // Ukrainski terapevticheski zhurnal. –2008. –№2. –S.13-20 [in Ukr].

Tepliakov A.T., Shilov S.N., Berezikova E.N. i soavt. Vliianie polimorfismov genov angiotensinogena I receptora 1-go typa angiotensina ІІ na razvitiie I techeniie chronicheskoi serdechnoi nedostatochnosti // Terapevticheskii arhiv. –2013. –Т.1. –S.14-19 [in Rus].

Tichonova S.A. Polimorfism genov receptorov angiotensina ІІ 1-go typa I sintasy aldosterona u molodych muzhchin s raznymy urovniamy arterialnogo davleniia I nasledstvennym anamnesom po hipertonicheskoi bolezni // Ukrainski terapevticheski zhurnal. –2008. –№3. –S.61-66 [in Rus].

Chaitovich N.V. Personalizirovannaia antihipertensivnaia terapiia // Medychna Nauka Ukrainy. –2015. –Т.11, –№1-2. –S.91-98 [in Rus].

Tseluiko V.I., Bregvadze T.P., Mishchuk N.E. i soavt. Polimorphism gena receptora angiotensina ІІ 1-go typa I ego vliianie na effectivnost terapii olmesartanom u pacientov s gipertonicheskoi bolezniiu // Ukrainski Kardiologicheski Zhurnal. –2013. –№4. –S.21-27 [in Rus].

Tseluiko V.I., Popova K.I. Geneticheskiie aspekty infarcta miocarda // Sertse i sudyny. –2008. –№1(21). –S.33-37 [in Rus].

Tseluiko V.I., Yakovleva L.M. Genetychni aspekty arterialnooi hypertensii u chvorych na ishemichnu chvorobu sertsia // Arterialnaia hipertensiia. –2013. –№5(31). –S.16-19 [in Ukr].

Tseluiko V.I., Yakovleva L.M., Kuznetsov I.V. Factory, shcho asotsiiyuiutsia z poshyrenistiiu aterosklerotichnogo processu u chvorych na ishemichnu chvorobu sertsia // Zhurnal clinichnych ta experimentalnych medychnych doslidxhen. –2013. –Т.1, №3. –S.301-307 [in Ukr].

Tseluiko V.I., Yakovleva L.M., Popova K.I. Factory, shcho vplyvaiiut na perebig infarctu miocarda u chvorych na ishemichnu chvorobu sertsia // Liky Ukrainy. –2013. –№3-4(16-17). –S.19-23 [in Ukr].

Shilov S.N. Chronocheskaia serdechnaia nedostatochnost pri ishemicheskoi bolezni serdsia: clinic-geneticheskiie mechanismy razvitiia i vozmozhnisti uluchsheniia rannei diagnostiki, profilaktiki I medikamentoznoi terapii. Avtoref. doctorskoi dissertatsii -2011. Tomsk. 32s. [in Rus].

Yakovleva L.M. Polimorfism geniv endotelialnooi NO-syntasy, angiotensin-peretvoriuchogo ferment ta receptora angiotansynu II typu 1 u chvorych na ishemichnu chvorobu sertsia z cukrovym diabetom // Klinichna medycyna. –2013. –Т.18, №4. –S.45-52 [in Ukr].

Akpinar T.S., Ozkok A., Kose M. et al. Endothelial constitutive nitric oxide synthase, angiotensin converting enzyme, angiotensin II type 1 receptor gene polimorphism and endothelial functions in healthy individuals // European Review for Medical and Pharmacological Sciences. –2014. –Vol.18 (1). –P.39-45.

Andrikopoulus G.K., Tzeis S.M., Needham E.W. et al. GEMIG study investigators. Lack of association between common polymorphisms in genes of the rennin-angiiotensin system and mortality after myocardial infarction // Cardiology. –2005. -Vol.103. –P.185-188.

Araujo M.A., Menezes B.S., Lourenco C. et al. The A1166C polymorphism of the angiotensin II type 1 receptor in acute myocardial infarction // Arq Bras Cardiol –2004. –Vol.83. –P.404-413.

Bayramogly A., Kurt H., Gunes H.V. et al. Angiotensin II type 1 receptor (AT1) gene A1166C is associated with the risk of hypertension // Genet Test Mol Biomarkers. -2015. –Vol.19(1). –P.14-17. DOI:10.1089/gtmb.2014.0233.

Benetos A., Giron A., Joly L. et al. Influence of the AGTR1 A1166C genotype on the progression of arterial stiffness: a 16-year longitudinal study // Am J Hypertens. -2013. –Vol.26. –P.1421-1427.

Bonnardeaux A., Davies E., Jeunmairtre X. et al. Angiotensin II type receptor gene polymorphisms in human essential hypertension // Hypertension. -1994. –Vol. 24. –P.63-69.

Cameron A., Mocatta T.J., Pilbrow A.P. et al. Angiotensin type-1 receptor A1166C gene polymorphism correlates with oxidative stress levels in human heart failure // Hypertension. -2006. –Vol.47. –P.1155-1161. DOI: 10.1161/01.HYP.0000222893.85662.cd

Canavy I., Henry M., Morange P. et al. Genetic polymorphisms and coronary artery disease in the south of France // Thromb Haemost. -2000. –Vol.83. –P.212-216.

Ceolotto G., Papparella I., Bortoluzzi A., et al. Interplay between miR-155, AT1R A1166C polymorphism, and AT1R expression in young untreated hypertensives // Am J Hypertens. – 2011. –Vol.24. –P.241–246. DOI: 10.1038/ajh.2010.211

Chandra S., Narang R., Sreenivas V. et al. Association of angiotensin II type 1 receptor (A1166C) gene polymorphism and its increased expression in essential hypertension: a case-control study // Plos one. -2014. –Vol.9 (14). –P.e101502. DOI:10.1371/journal.pone.0101502.

Delshad N., Ghayour-Mobarhan M., Mirzaei H., et al. Angiotensin II type 1 receptor gene A1166C polymorphism was not associated with acute coronary syndrome in an iranian population. Iran Red Crescent Med. 2016; 18(11):e23942. DOI:10.5812/ircmj.23942.

Diez J., Laviades C., Orbe J. et al. The A1166C polymorphism of the at1 receptor gene is associated with collagen type 1 synthesis and myocardial stiffness in hypertensives // J Hypertens. -2003. –Vol.21. –P.2085-2092.

El-banawy H., Bedair R., Mohammed A. Angiotensin II type 1 receptor (A1166C) gene polymorphism in Egyptian adult hemodialysis patients // Alexandria Journal of Medicine. -2015. –Vol.51. –P.339-345.

Fan X.N., Li L., Qui C.G., et al. Analysis of the relationship between angiotensin 2 type 1 receptor gene polymorphism and the severity of coronary artery stenosis // J Zhengzhou University (Medical Sciences). -2004. –Vol.39. –P.584-586.

Flippi-Condaccioni E., Morelo R., Fradin S. et al. Relation between the A1166C angiotensin II type 1 receptor gene polymorphism and cardiovascular outcomes after myocardial infarction // Eurointervention. -2005. –Vol.1 (1). –P.38-42.

Gardemann A., Nguyen Q.D., Humme J. et al. Angiotensin II type 1 receptor A1166C gene polumorphism. Absence of an association with the risk of coronary artery disease and myocardial infarction and of a synergistic effect with angiotensin-converting enzyme gene polymorphism on the risk of these diseases // Eur.Heart J. -1998. –Vol.19. –P.1657-1665.

Guimond M.O., Gallo-Payet N. The angiotensin II type receptor in brain functions: an update // International Journal of Hypertension. -2012. Article ID 351758, 18 pages. DOI: 10.1155/2012/351758.

Katsuya T., Morishita R. Gene polymorphism of angiotensin II type 1 and type 2 receptors // Curr Pharm Des. -2013. –Vol.19(17). –P.2996-3001.

Kaur R., Das R., Ahluwalia J. et al. Synergistic effect of angiotensin II type-receptor 1166A/C with angiotensin-converting enzyme polymorphism on risk of acute myocardial infarction in North Indians // J.Renin angiotensin Aldosteron Syst. -2012. –Vol.13. –P.440-445.

Kolakovic A., Zivkovic M., Stankovic A. et al. Involvement of renin-angiotensin system in atherosclerosis // Renin-Angiotensin system – past, present and future. -2017. –P.15-38.

Konopka A., Szperl M., Piotrowski W., Stepinska J. Polymorphisms of angiotensin II type 1 receptor gene and those of angionensinogen point at culprit artery in ST-segment elevation myocardial infarction // Gene.-2012. –Vol.500 (1). –P.148-150. DOI: 10.1016/j.gene.2012.03.014.

Kooffrch M.E., Anumundu C.I., Duke R. et al. Angiotensin II type 1 receptor A1166C gene polymorphism and essential hypertension in Calabar and Uyo cities, Nigeria // Indian J Hum Genet. -2013. –Vol.19. –P.213-218.

Kruzliak P., Kovacova G., Pechanova O., Balogh S. Association between Angiotensin II type I receptor polimorghism and sudden cardiac death in myocardial infarction // Dis. Markers. -2013. –P.35(5). –P.287-293.

Li Y., Li X., Jia N. et al. Meta-analysis of the association between angiotensin II receptor, type 1 gene A1166C polymorphism and coronary artery disease in Chinese populations // Journal of the Renin-Angiotensin Aldosterone System. -2013. –Vol.14, Suppl.1. –P.82–90. DOI: 10.1177/1470320312450599 jra.sagepub.com

Lozinski S. The association of A1166C gene polymorphism of angiotensin receptors with the parameters of central pulse wave in normotensive persons and patients with hypertension. Folia Cardiologia. 2016; 11(3): 180-185. doi:10.5603/fc.2016.0028.

Martinez-Quintata E., Chirino R., Nieto-Lago V. et al. Prognostic value of ACE I/D, AT1R A1166C, PAI-1 3G/5G and GPIIIa a1/a2 polymorphisms in myocardial infarction // Cardiol J. -2014. –Vol.21, Suppl. 3. –P.229-237. DOI: 10.5603/CJ.a2013.0107

Mehri S., Mahjoub S., Finsterer J. et al. The CC genotype of the angiotensin II type 1 receptor gene independently associates with acute myocardial infarction in a tunisian population // Journal of Renin-Angiotensin-Aldosterone System. -2011. –Vol.12(4). –P.595-600. DOI:10.1177/1470320310391833.

Mishra A., Srivastava A., Kumar S. et al. Role of angiotensin II type 1 (AT A1166C) receptor polymorphism in susceptibility of left ventricular sysfunction. // Indian Heart Journal. -2015. –Vol.67. –P.214-221.

Mottl A.K., Shoham D.A., North K.E. Angiotensin II type 1 receptor polymorphism and susceptibility to hypertension: a HuGE review // Genetics in Medicine. -2008. –Vol.10. –P.560-574. DOI:10.1097/GIM.obo13e3181809613.

Moustafa M., Hassanin O.M., Abdel-Rahman E. et al. Associations between human aldosterone synthase (CYP11B2) and Angiotensin II type 1 receptor (ATR1) gene polymorphisms with end stage renal disease in hypertensive Egyptian patients on maintenance hemodialysis // ASRJETS. -2015. –Vol.14(1). –P.12-22

Nossent A.Y., Hansen J.L., Doggen C., et al. SNPs in microRNA binding sites in 3-UTRs of RAAS genes influence arterial blood pressure and risk of myocardial infarction // Am J Hypertens. –2011. –Vol.24. –P.999–1006. DOI: 10.1038/ajh.2011.92

Ozturk O., Ozturk U., Negriz S. et al. The relationship between Angiotensin-II type I receptor gene polymorphism and repolarization parametres after a first anterior acute myocardial infarction // Korean Circ J. -2016. –Vol.46, Suppl.6. –P. 791-797. DOI: 10.4070/kcj.2016.46.6.791

Ramu P., Umamaheswaran G., Shewade D.G. et al. Candidate gene polymorphism of renin angiotensin system and essential hypertension in a South Indian Tamilian population // Int J Hum Genet. -2011. –Vol.11. –P.31-40.

Reddy B., Muni B., Venkata K. et al. Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patients // J Renin Angiotensin Aldosterone Syst. -2009. –Vol.10(3). –P.174-178.

Reid I.A. The renin-angiotensin system: physiology, patophysiology, and pharmacology. Adv Physiol Educ. 1998; 275:236-245.

Shamaa M. Angiotensin II type 1 receptor (A1166C) gene polymorphism and essential hypertension in Egypt // Journal of Integrative Cardiology. -2015. –Vol.1(3). –P.65-68.

Stankovic A., Kolakovic A., Zivkovic M. et al. Angiotensin receptor type 1 polimorphism A1166C is associated with altered AT1R and mir-155 expression in carotid plaque tissue and development of hypoechoic carotid plaques // Atherosclerosis. -2016. –Vol.248. –P.132-139.

Tian J., Shunying Hu, Wang F. et al. PPARG, AGTR1, CXCL16 and LGALS2 polymorphisms are correlated with the risk for coronary artery disease // Int J Clin Exp Pathol. –2015. –Vol.8 (3). –P.3138-3143.

Tiret I., Bonnardeaux A., Poirier O. et al. Synergistic effects of angiotensin-converting enzyme and angiotensin-II type 1 receptor gene polymorphisms on risk of myocardial infarction // Lancet. -1994. –Vol.344. –P.910-913.

van Geef P.P., Pinto Y.M., Voors A.A. et al., Angiotensin II type 1 receptor A1166C gene polymorphism is associated with an increased responce to angiotensin II in human arteries // Hypertension. -2000. –Vol.35(3). –P.717-721.

Yang Y., Tian T., Lu J. et al. A1166C polymorphism of the angiotensin II type 1 receptor gene contributes to hypertension susceptibility: evidence from a meta-analysis // Acta Cardiol. -2017. –Vol.72 (2). –P.205-215. DOI: 10.1080/00015385.2017.1291211.

Wang J.L., Li X., Hao P.P et al. Angiotensin II type receptor gene A1166C polymorphism and essential hypertension in Chineese: a meta-analysis // J Renin angiotensin Aldosteron Syst. -2010. –Vol.11(2). –P.127-135. DOI: 10.1177/1470320310364181.

Weir R.A.P. Pathophysiological role of Aldosterone in Cardiac remodeling after myocardial infarction. A thesis submitted for the degree of Doctor of Medicine in the Faculty of Medicine of the University of Glasgow. -2009. -327p.

Zhang K., Zhou B., Zhang L. Association study of angiotensin II type I receptor: A1166C (rs5186) polymorphism with coronary heart disease using systematic meta-analysis // J Renin-Angiotensin-Aldosteron System. -2012. –Vol.0(0). –P.1-8. DOI:10.1177/1470320312447652 jra.sagepub.com




© Український терапевтичний журнал, 2018
© ПП «ІНПОЛ ЛТМ», 2018