Поліморфні варіанти A1166C гена АТІІR1 у хворих на серцево-судинну патологію

Автор(и)

  • O. V. Petyunina ДУ «Національний інститут терапії імені Л.Т. Малої НАМН України», Харків

Ключові слова:

поліморфізм гена ATIIR1 А1166С, серцево-судинні захворювання.

Анотація

В огляді представлено аналіз даних щодо ролі поліморфних варіантів A1166C гена рецепторів 1 типу до ангіотензину ІІ (АТІІR1) при артеріальній гіпертензії, серцевій недостатності, інфаркті міокарда. Показано, що ген АТІІR1 є геном-кандидатом, якому притаманні властивості самостійного фактора серцево-судинного ризику. Поліморфізм А1166С гена ATIIR1 асоціюється не тільки з модифікацією ефектів ренін-ангіотензин-альдостеронової системи, а й їхнім впливом на перебіг серцево-судинних захворювань та фенотиповими проявами.

Біографія автора

O. V. Petyunina, ДУ «Національний інститут терапії імені Л.Т. Малої НАМН України», Харків

к. мед. н., ст. наук. співр. відділу профілактики та лікування невідкладних станів 
Петюніна Ольга В’ячеславівна

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